Dr Bhikhu Patel, who graduated from the University of Bristol 45 years ago, has returned with his wife Shashi to donate a million pounds.
He graduated with a degree and PHD in architecture in 1973.
The money will be used for the £300 million project going on in the Temple Quarter area.
Dr Patel said, “I am so grateful for everything education has given me in life. I want others to benefit in the same way – helping the next generation to become entrepreneurs and innovators of the future.
“Bristol’s new campus will attract the best and brightest from around the world. It will be a very stimulating teaching environment, combining the classroom with business and industry.
“Entrepreneurship is in my blood and so many modern institutions don’t cater for this. TQEC will answer this in a very exciting way.”
The project will focus on business education alongside science and engineering. It will add more students’ housing and a new campus.
The university’s vice-chancellor, Professor Hugh Brady, said: “Our new campus will be a beacon of collaboration, innovation and opportunity.
“I would like to thank Bhikhu and Shashi for their tremendous generosity and look forward to working with them and other key partners as we bring this new campus to life.”
The Patels have also set up the Bhikhu and Shashikala Patel Student Support Fund. Through scholarship and bursaries, it helps diverse students with financial aid.