New technology, developed by the University of Bristol


Researchers at the University of Bristol have conceived a modern technology that could result in the growth of a new generation of smart medical glues and bandage for lingering wounds. The new procedure, started by Dr. Adam Perriman and associates, comprise re-engineering stem cells membranes to weld the cells together successfully.

Cell membrane re-manufacturing is arising as a powerful tool for the growth of next-generation cell treatments as it lets experts provide new functions in the therapeutic cells like adhesion, homing, or hypoxia resistance. Presently, there are a few instances where the cell membrane is reproduced to exhibit active enzymes that propel extracellular matrix production, considered a vital progression in wound healing.

The procedure converts natural enzymes into a tissue binding protein

In this study, published on the 23rd of April by Nature Communications, the team customised the membrane of human mesenchymal stem cells with enzyme thrombin, implicated in the injury healing process. When the altered cells were positioned in a solution with the blood protein fibrinogen, they inevitably welded together through the development of a natural hydrogel from the cells surface. The scientists have also revealed that the subsequent 3D cellular structures could apply for tissue production.

The new method could pave the way for the expansion of other biotechnologies

Dr. Adam Perriman said that one of the greatest challenges in cell treatments is the necessity to safeguard the cells from harsh environments after transplantation. Perriman works in the School of Cellular and Molecular Medicine as an Associate professor in Biomaterials.

The investigators have renovated an entirely new technology that permits cells to develop their artificial extracellular matrix, aiding cells to safeguard themselves and letting them increase after transplantation. The group’s findings could boost the likelihood of tissue production for long-lasting wound healing, mainly because the procedure uses fibrinogen which is plentiful in blood.


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